Massive Russian strikes on Ukraine’s second-largest city killed at least five people on Saturday, officials said, one night after Moscow carried out one of the war’s largest aerial assaults on Ukraine.

Ukraine says that a large Russian drone-and-missile attack has targeted the eastern city of Kharkiv, killing at least three people and injuring 21.

Air assaults on Saturday killed at least four people. Kharkiv’s mayor described an overnight strike as “the most powerful attack” since the beginning of the war.