Publishes original research, insights and opinions on evidence-based research. Focuses on the tools, methods, and concepts that are central to practising evidence-based medicine.

Health technology assessment (HTA) is a multidisciplinary process that uses explicit methods to determine the value of a health technology at different points in its lifecycle.1 ,2 Its aim is to ...

136 Real-world evidence comparing the vitamin-K-antagonist phenprocoumon versus direct oral anticoagulants in patients with atrial fibrillation in Germany ...

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RRs) use modified systematic review methods to accelerate the review process ...

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RR) use modified systematic review methods to accelerate the review process ...

To practice high quality healthcare, clinicians must be able to diagnose correctly, provide preventative and treatment interventions based on the best available evidence, and ensure decisions are ...

Objectives To compare the effectiveness of different exercise interventions in improving sleep quality and alleviating insomnia severity among patients with insomnia. Design Our study design was a ...

The introduction of generative large language models (LLMs) has led to the exploration of their use in evidence synthesis tasks, such as literature searches,1 screening,2 3 risk of bias assessment,4 5 ...

Objectives Endometrial cancer (EC) incidence has been rising globally, while mortality has remained stable, particularly in Nordic countries. This study aimed to explore the role of transvaginal ...

Objectives To investigate the efficacy of non-surgical and non-interventional treatments for adults with low back pain compared with placebo. Eligibility criteria Randomised controlled trials ...

There is a recognised knowledge deficit about the absolute size of benefits and harms of treatments among clinicians1 2 restricting the possibility of good quality shared decision-making3 4 and ...

Open scholarship practices—often also referred to as open research or open science—are increasingly seen as relevant to the research lifecycle. What open scholarship looks like in practice will ...