Spencer Torkelson had a pair of hits, walked twice and drove in a run to help the Tigers beat the St. Louis Cardinals 5-1 for Detroit’s 15th win in its past 20 games.

The Cleveland Guardians (26-22) and the Detroit Tigers (33-17) open a 4-game series Thursday at Comerica Park in Detroit. First pitch is scheduled for 6:40 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the Guardians vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

The Tigers are still first in the American League Central, while the Cardinals are second in the National League Central. Time: 1:15 p.m. ET Where: Busch Stadium (St. Louis, Mo.)

Detroit will travel home to host the Cleveland Guardians on Thursday, May 22, 2025. The first pitch is scheduled for 6:40 p.m. With the victory, the Tigers improved to 33-17 while putting the league on notice. For the first time since 2006, the 2025 ball club has the best record in the show through 50 games.

Preview the May 21 matchup between the St. Louis Cardinals and Detroit Tigers with odds over/under, game spread, betting lines and more.

A sextet of relievers effectively covered the nine innings Wednesday and the Tigers were able to get out of St. Louis with another series win.

Monday's game is set to restart at 9:15 p.m. CT, weather permitting. Hopefully, Mother Nature cooperates enough to get another two innings in.

Riley Greene went 3-for-4 with a homer, the decisive double in the ninth inning and four RBIs, powering the visiting Detroit Tigers past the St. Louis Cardinals 5-4 on Tuesday.