In a recent interview with Entertainment Weekly, Bruckheimer revealed that he has spoken to Depp about coming back for the sixth Pirates film, and the actor is at least open to the idea. The famous Producer explained: If he likes the way the part's written,

Source material can come from everywhere. We live in a world where a mobile game can become an animated franchise, and a supposedly haunted doll can inspire a successful horror series. But perhaps the best example of making a lot with a little is Pirates of the Caribbean, the epic pirate fantasy series inspired by a Disney theme park ride.